Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• enhancing SOD, GPx, and CAT activities [166]. Second, nanoantioxidants can be used to support cancer therapies such as photodynamic therapy (PDT) and photothermal therapy (PTT) [167]. In this strategy, nanomaterials with antioxidant activities enhance PDT and PTT efficacy by reducing hypoxia in the tumor

• , Kharlamov et al. investigated 180 patients diagnosed with coronary artery disease (CAD). Their findings unveiled a notable regression of coronary atherosclerosis associated with plasmonic photothermal therapy using silica–gold NPs (SiO2-AuNPs) [177]. Metal-based NPs exhibit the ability to scavenge free

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• photothermal therapy on a single platform has been developed in the form of vinorelbine-loaded polydopamine-coated iron oxide nanoparticles. Vinorelbine (VNB) is loaded on the surface of iron oxide nanoparticles produced by a solvothermal technique after coating with polydopamine (PDA) with varying weight

• ., cancer, diabetes, and atherosclerosis), magnetic resonance imaging (MRI), targeted drug delivery, photothermal therapy, gene therapy, and molecular and cellular monitoring [15][16]. Photothermal therapy (PTT), a treatment in which nanostructures are used, induces drug release or damages tumor cells with

• the heat produced by nanostructures under NIR laser irradiation [17][18]. Compared to traditional treatments, photothermal therapy allows for increased drug release and is less cytotoxic to healthy tissues [19]. It is a minimally invasive technique that offers the advantage of rapid recovery [20

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• (nanocages, nanorods, and nanohexapods) for photothermal therapy. All three nanostructures exhibited NIR absorption and could convert light into heat, with the gold nanohexapods having the highest efficiency [66] (Figure 6F,G). Branched gold nanostructures (Figure 6D,E) showed higher photothermal activity

• than spherical nanoparticles [62][64][67]. It was also shown that gold nanobipyramids have a more adjustable absorption wavelength and higher chemical stability than other gold nanostructures, which makes them suitable candidates for photothermal therapy [67]. Another well-known nanomaterial with

• such as photothermal therapy, imaging, and LFAs [73]. Composition-dependent photothermal properties Recently, nanocomposite materials have been employed for the development of photothermal biosensors for the detection of cancer biomarkers or whole cancerous cells, antibiotic residues, and toxins [74

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• ]. The precisely targeted thermal killing of tumor tissue can help to improve the efficiency of energy utilization and reduce power and time during ablation, which will minimize damage to normal tissue around the tumor [95]. Photothermal therapy (PTT) can generate thermal energy by using near-infrared

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• nanoarchitectures to promote photothermal therapy In photothermal therapy, light energy is converted to thermal energy, which ultimately kills malignant cells [86]. In general, tumors are less resistant to heat than normal tissues. Advantageously, even light of long wavelengths is directly employable. Furthermore

• molecules were threaded into the polymer chains) [87]. NIR light (808 nm) was absorbed by graphene oxide and converted into heat for photothermal therapy. At the same time, the heat induces the gel–sol transition of the hydrogel to release the encapsulated drug which add to the photothermal effect for

• temperature elevation by the photothermal effect induces gel–sol transition of the nanomedicine, which the release of encapsulated cisplatin from the hydrogel. Mitochondria-targeting photothermal therapy was accomplished by two-dimensional nanoassemblies, prepared from β-CyD-grafted graphene oxide and

Concentration-dependent photothermal conversion efficiency of gold nanoparticles under near-infrared laser and broadband irradiation

• Vikas,
• Raj Kumar and
• Sanjeev Soni

Beilstein J. Nanotechnol. 2023, 14, 205–217, doi:10.3762/bjnano.14.20

• ]. Localized heat generation through GNPs under irradiation can be used for hyperthermia treatment of tumors, termed plasmonic photothermal therapy (PPTT) [7][8][9][10][11]. The net temperature rise of a GNP-containing medium highly depends on shape and size of the GNPs, the dielectric constant of the medium

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

• Yuran Wang,
• Xudong Li,
• Haijun Chen and
• Yu Gao

Beilstein J. Nanotechnol. 2022, 13, 1432–1444, doi:10.3762/bjnano.13.118

• Synthesis and Function Discovery (Fujian Province University), Fuzhou University, Fuzhou 350116, Fujian, China 10.3762/bjnano.13.118 Abstract Gold nanoparticles with large size exhibit preferable properties for photothermal therapy (PTT). However, the prolonged tissue retention and slow elimination of gold

• synergistic PTT in the treatment of cancer and other diseases. Keywords: BODIPY; gold nanoparticles; lipid nanoparticles; photothermal therapy; synergism; Introduction Photothermal therapy (PTT) relies on photothermal agents (PTAs) to convert light into heat energy to burn cancer cells. Due to its spatial

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

Photothermal ablation of murine melanomas by Fe₃O₄ nanoparticle clusters

• Xue Wang,
• Lili Xuan and
• Ying Pan

Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20

• development of resistance. Here, we fabricated Fe3O4 nanoparticle clusters (NPCs), which have drawn widespread attention, and investigated their role in the treatment of melanoma by photothermal therapy (PTT). Scanning electron microscopy imaging shows that our synthesized NPCs are spherical with an average

• the promise of Fe3O4 NPCs as a new PTT option to treat melanoma. Keywords: Fe3O4 nanoparticle clusters; heat shock protein 70; melanoma; near infrared; photothermal therapy; Introduction The global incidence of melanoma, one of the deadliest forms of cancer, has kept increasing annually over the

• afterwards due to adverse effects or development of various resistance mechanisms, making the advent of novel strategies imperative for early diagnosis and efficient treatment [2]. Photothermal therapy (PTT) is a recently developed regimen that requires administration of nanomaterials with unique optical

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• biomedicine. Titania nanomaterials for phototherapeutic applications Phototherapy breakthroughs, including photodynamic therapy (PDT) and photothermal therapy (PTT), have established new frontiers in the therapy of cancer and other chronic diseases. The process of inducing cell death using ROS-producing

Self-assembly of amino acids toward functional biomaterials

• Huan Ren,
• Lifang Wu,
• Lina Tan,
• Yanni Bao,
• Yuchen Ma,
• Yong Jin and
• Qianli Zou

Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85

• diagnosis and treatment because of its strong absorption ability in the near-infrared region [84]. However, ICG has poor stability and a short half-life, thus limiting its use in photothermal therapy. Liu et al. [85] developed a nanoparticle based on phenylalanine, geniposide, and ICG for antitumor

• photothermal therapy. Geniposide is a natural crosslinking agent that provides strong covalent interactions to enhance stability. In addition, they attached disulfide groups to phenylalanine in response to glutathione. The obtained nanoparticles (GDSP) have high stability and can improve the photostability and

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• factors that determine the effectiveness of phototherapy against cancer cells [142]. For example, Rahimi-Moghaddam et al. [140] reported a higher cytotoxic effect of a gold–CUR nanosystem used as photothermal therapy against breast cancer cells when exposed to an 808 nm laser (1.5 W/cm2), as compared to a

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Rapid controlled synthesis of gold–platinum nanorods with excellent photothermal properties under 808 nm excitation

• Jialin Wang,
• Qianqian Duan,
• Min Yang,
• Boye Zhang,
• Li Guo,
• Pengcui Li,
• Wendong Zhang and
• Shengbo Sang

Beilstein J. Nanotechnol. 2021, 12, 462–472, doi:10.3762/bjnano.12.37

• photothermal stability. Our work has paved the way for the controllable synthesis of Au@Pt NRs with specific optical properties and stable photothermal performance. The Au@Pt NRs are capable of acting as a novel PTAs and show good application prospects in the photothermal therapy of tumors. Experimental

Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• study was to fabricate biocompatible multifunctional drug-loaded nanoscale moieties for co-therapy (chemo-photothermal therapy) with maximum efficacy and minimum side effects. Herein, we report in vitro anticancerous effects of doxorubicin (DOX) loaded on gold nanorods coated with the polyelectrolyte

• based on chemotherapy and photothermal strategies appears to be a promising platform in cancer management. Keywords: chemotherapy; doxorubicin; gold nanorods; NIR laser; photothermal therapy; Introduction Despite the enormous advances in medical research, cancer is still the second most common cause

• be obtained by utilizing external stimuli, such as pH value, light, or ultrasound, to deliver the anti-cancerous drug into tumor tissue with spatial and temporal control [14]. Photothermal therapy (PTT) is an emerging minimally invasive cancer therapy. It can efficiently induce cytotoxicity by

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• standard cancer treatments. When used in combination with chemotherapy, radiotherapy or radiofrequency ablation, or photothermal therapy, the final outcome of the combined therapy would be more beneficial to the patient, although in clinical practice, physicians are reluctant to use these methods [136][153

• papers even report a better heating efficacy for SPIONs formulated as magnetosomes used in photothermal therapy than for magnetized cubic SPIONs. The authors demonstrated that magnetization hyperthermia is up to two orders of magnitude less effective in cells and tissues than in water. In contrast

• , photothermal therapy is not influenced by tissues leading, therefore, to an up to 1000 times better heating efficacy than magnetization, but only at significant concentrations of at least 500 µg/mL or 25 mg/kg [113][154]. In MRI, SPIONs work as negative contrast agents and can be localized and identified by

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• , making these particles interesting for tumor treatment by photothermal therapy [178]. Furthermore, nanorods can be internalized more easily by cells as their increased surface allows them to interact more easily with receptors on the cell membranes [181]. AuNRs have been functionalized to increase their

Luminescent gold nanoclusters for bioimaging applications

• Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

• allowed for plasmonic and magnetic resonance, and luminescence in a single composite system for plasmonic photothermal therapy (PPTT). The bioimaging capability of the plasmonic magneto-luminescent multifunctional nanocarrier (PML-MF) systems were studied in vitro using three types of cancer cells, namely

• potential for photothermal therapy. While PML-MF alone was not toxic to healthy HEK cell lines, the treatment with DPML-MF showed a similar antiproliferative effect on healthy cell lines as that of cancerous cells. Therefore, the selective killing of cancer cells was not achieved. The superparamagnetic

• ) Schematic representation of the fabrication of the PML-MF nanocarriers and their application in photothermal therapy. B) CLSM images of HeLa, HepG2, A375, and HEK cells treated with the PML-MF nanocarrier for 2 h; images were recorded with a 488 nm excitation laser. C) In vitro magnetic targeting of HeLa

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• , the porphyrin photosensitizer was released and the size of the nanoobjects in solution increased (Figure 5d) [77]. For a combined photodynamic therapy/photothermal therapy (PDT/PTT) approach, indocyanine green (ICG) has been encapsulated in a protein, namely human serum albumin. First human serum

• design point to the development of versatile and “all in one” nanocarriers embedding different functions in order to both visualize the tumor and kill it. For this purpose, PDT has been associated with multimodal imaging and other treatments such as chemotherapy or photothermal therapy (PTT). Doxorubicin

Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• nanoparticles [34]. The resulting gold–alendronate nanoplatform combines antitumor activity through drug delivery and photothermal therapy, as illustrated in vitro on the inhibition of prostate cancer cells. In the field of hybrid coordination networks, new lanthanide-based networks synthesized by a solvo

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• dual-functionalized GO for the photothermal enhancement of gene delivery [23]. Xiong et al. studied the synergistic effects of PEG-functionalized GO for chemo-photothermal therapy [24]. Tian et al. revealed that PEG-GO enhanced the uptake of chlorin e6 by cancer cells [25]. Shen et al. exploited the

• nGO in organs including lung, liver, and spleen and promoted its clearance from these organs [28]. Zhang et al. treated a tumour with a chemo-photothermal therapy based on PEG-GO [29]. The safety and tumour accumulation of PEG-GO has been reported by Miao and co-workers [30]. Functionalized PEG-nGO

Tungsten disulfide-based nanocomposites for photothermal therapy

• Tzuriel Levin,
• Hagit Sade,
• Rina Ben-Shabbat Binyamini,
• Maayan Pour,
• Iftach Nachman and
• Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

• the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method

• -step functionality. This ability is demonstrated here with two polymers grafted onto the nanocomposite surface, and other functionalities could be additional cancer therapy agents for achieving increased therapeutic activity. Keywords: cerium complex; magnetic nanoparticles; photothermal therapy

• engineering, and their incorporation in dental devices [25][26][27][28][29][30][31][32]. Another important medical application for nanostructures in general, and for TMDC nanostructures in particular, is targeted cancer treatment through photothermal therapy (PTT). In this method, light-responsive materials

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• fluorescent imaging and plasmonic phothothermal abilities have not been reported previously. The multifunctional nanoparticles were stable in cell buffer, nontoxic and suitable for targeted fluorescent imaging and photothermal therapy of cancer cells. We demonstrate the enhanced accumulation of folate

• designed parameters [3][4]. The AuNRs themselves can serve as contrast agents for two-photon [5][6], photoacoustic [7][8][9] and SERS [10][11] imaging, and for plasmonic photothermal therapy (PPT) [12][13]. However, the as-prepared AuNRs demonstrate high toxicity [14][15] and low stability in biological

• loading with rhodamine 123 makes the nanoparticles suitable for cell imaging with a simple fluorescent microscope; (3) through using NIR-mediated photothermal therapy the cancer cells can be killed with a high efficiency. Results and Discussion Synthesis and characterization of the AuNRs-PDA-R123-folate

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• stability and biocompatibility of GNRs has been reported by several researchers, and they are being investigated as a probe for photothermal therapy in nanomedicine. The presence of longitudinal surface plasmon resonance (LSPR) provides GNRs with richer optical properties, which lead to local field, Raman